Accumulation in Visceral Adipose Tissue Over 6 Years Is Associated With Lower Paraspinal Muscle Density
Errata to this article were published (J Clin Endocrinol Metab, 17 May 2023 ↗ · 18 Oct 2023 ↗)
Authors' conclusion
These results highlight that age-related accumulation of VAT in men and women is associated with lower muscle density. VAT may represent a modifiable risk factor for poor musculoskeletal outcomes with aging.
Study context
- Population
- Framingham Study third-generation cohort participants with quantitative CT scans of the spine at baseline and 6-year follow-up
- Participants
- 1,145 participants
- Exposure
- Per 100-cm³ increase in visceral adipose tissue (VAT) over 6 years
- Outcome
- Paraspinal muscle density at follow-up
- Follow-up
- 6-year follow-up
Methodological detailsFramingham Study third-generation cohort, 6-year follow-up, sex-stratified multiple regression
- Framingham Study third-generation cohort
- 6-year follow-up
- Sex-stratified multiple regression
Main finding
As reported in the abstract
Paraspinal muscle density (HU) per 100-cm³ increase in VAT
Lower muscle density (HU) per 100-cm³ VAT increase, men
0.302
95% CI −0.380 to −0.224P < .001
Lower muscle density (HU) per 100-cm³ VAT increase, women
0.476
95% CI −0.598 to −0.354P < .001
Observational data: associations, not effects.
Original publication
Accumulation in Visceral Adipose Tissue Over 6 Years Is Associated With Lower Paraspinal Muscle Density. J Clin Endocrinol Metab. Published 22 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →