An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial
Authors' conclusion
Lower HbA1c levels among individuals with diabetes are associated with slower biological aging as captured by a deficit accumulation FI. Strategies to control diabetes through weight loss or metformin use may also slow aging.
Study context
- Population
- Participants with T2D aged 45–76 years followed in the Look AHEAD RCT
- Participants
- 4,169 pooled across arms
- Comparison
- HbA1c <7% vs ≥8%; diabetes medication classes and weight change
- Primary endpoint
- Change in deficit accumulation frailty index (FI)
- Follow-up
- 8 years
Methodological detailsexploratory, ancillary, pooled across intervention groups, inverse probability weighting for differential follow-up
- Exploratory
- Ancillary
- Pooled across intervention groups
- Inverse probability weighting for differential follow-up
Primary result
As reported in the abstract
Increase in FI scores
- HbA1c <7% vs HbA1c ≥8%: both P ≤ 0.002
Further findings
Frailty index (FI) change by metformin use and weight loss, adjusted for HbA1c · 8 years
- Metformin use and weight loss >5% independently associated with slower increases in frailty
Original publication
An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial. Diabetes Care. Published 21 December 2022. doi:10.
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