Different Types of Industry-Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes: Findings From the NutriNet-Santé Prospective Cohort
Main finding · T2D risk by total TFA intakeResult — go to the resultHazard ratio 1.38 95% CI 1.11–1.73Authors' conclusion
In this large prospective cohort, higher intakes of total and iTFAs were associated with increased type 2 diabetes risk. These findings support the World Health Organization's recommendation to eliminate iTFAs from the food supply worldwide. Consumers should be advised to limit the consumption of food products containing partially hydrogenated oils (main vector of iTFAs). This may contribute to lowering the substantial global burden of type 2 diabetes.
Study context
- Population
- Adults age >18 years, French NutriNet-Santé cohort (2009–2021); mean baseline age 42.7 years (SD 14.6); 79.2% women969 incident cases
- Participants
- 105,551 participants
- Exposure
- Sex-specific quartile 4 vs 1 of dietary TFA intake
- Outcome
- Incident T2D
Methodological detailsmultivariable Cox models, repeated 24-h dietary records
- Multivariable Cox models
- Repeated 24-h dietary records
Main finding
T2D risk by total TFA intake
Hazard ratio
1.38
95% CI 1.11–1.73
P < 0.001 for trend
Quartile 4vs Quartile 1
HR 1.38 (95% CI 1.11–1.73); P for trend < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| T2D risk by industry-produced TFA (iTFA) intake | 1.45 (1.15–1.83) | P for trend < 0.001 | |
| T2D risk by elaidic acid intake | 1.37 (1.09–1.72) | P for trend < 0.001 | |
| T2D risk by linolelaidic acid intake | 1.29 (1.04–1.58) | P for trend = 0.07 | |
| 0.512Hazard ratio (log scale) |
T2D risk by ruminant TFA intake
- Ruminant trans fatty acids (TFAs) were not significantly associated with T2D risk
Original publication
Different Types of Industry-Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes: Findings From the NutriNet-Santé Prospective Cohort. Diabetes Care. Published 21 December 2022. doi:10.
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