Difference of Risk of Pancreatic Cancer in New-Onset Diabetes and Long-standing Diabetes: A Population-based Cohort Study
Authors' conclusion
The risk of pancreatic cancer was greater in people with DM than in a non-DM population. Among people with DM, NODM showed a higher risk of pancreatic cancer than LSDM.
Study context
- Population
- People with DM and matched non-DM controls, Korean National Health Insurance Service-National Sample Cohort, 2002–20131:1 matched cohort
- Exposure
- DM vs matched non-DM population
- DMn = 88,396
- Outcome
- Incidence of pancreatic cancer
Methodological details1:1 propensity score matching, multivariate time-dependent Cox regression
- 1:1 propensity score matching
- Multivariate time-dependent Cox regression
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
NODMvs Non-DM
3.81(2.97–4.88)
P < 0.001LSDMvs Non-DM
1.53(1.11–2.11)
P < 0.001- New-onset diabetes mellitus (NODM) vs long-standing DM (LSDM)
- HR 1.55; P = 0.020
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Pancreatic cancer risk, NODM subgroups vs matched same-sex or same-age non-DM controlsNODM (men)vs Non-DM (men) | 4.42 (3.15–6.19) | P < 0.001 | |
| Pancreatic cancer risk, NODM subgroups vs matched same-sex or same-age non-DM controlsNODM (in their 50s)vs Non-DM (in their 50s) | 7.54 (3.24–17.56) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Difference of Risk of Pancreatic Cancer in New-Onset Diabetes and Long-standing Diabetes: A Population-based Cohort Study. J Clin Endocrinol Metab. Published 22 December 2022. doi:10.
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