New users of sodium-glucose cotransporter 2 inhibitors are at low risk of incident pancreatic cancer: A nationwide population-based cohort study
Main finding · GI cancersResult — go to the resultAdjusted hazard ratio 0.90 95 % CI 0.82–0.99Authors' conclusion
For T2D patients, SGLT2i use was associated with a diminished pancreatic cancer risk compared to oGLMs. Future studies should ascertain the potential protective effect of SGLT2is against pancreatic cancer.
Study context
- Population
- Patients with T2D, nationwide National Health Insurance Service database, Republic of Korea, September 2014 to June 2020propensity score matched
- Participants
- 59,954 vs 59,954
- Exposure
- SGLT2i vs other glucose lowering medications
- SGLT2isn = 59,954
- Other glucose lowering medications (oGLMs)n = 59,954reference
- Outcome
- Incidence of gastrointestinal (GI) cancers (stomach, colorectal, liver and pancreatic)
Methodological detailsactive-comparator, new-user, propensity score matched
- Active-comparator
- New-user
- Propensity score matched
Main finding
GI cancers
Adjusted hazard ratio
0.90
95 % CI 0.82–0.99
Events by group
SGLT2is
814
events
oGLMs
916
events
SGLT2isvs oGLMs
aHR 0.90 (95 % CI 0.82–0.99)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95 % CI) | |
|---|---|---|
| Pancreatic cancerOnly cancer type significantly lower with SGLT2is · propensity score matched | 0.72 (0.55–0.95) | |
| 0.512Adjusted hazard ratio (log scale) |
Events
| Outcome | SGLT2is | oGLMs |
|---|---|---|
| Deaths · observation period | 794 | 1,140 |
Pancreatic cancer, entire cohort
- Multivariable-adjusted HR for pancreatic cancer in the entire cohort
- 0.70 (95 % CI: 0.56 to 0.88)
Original publication
New users of sodium-glucose cotransporter 2 inhibitors are at low risk of incident pancreatic cancer: A nationwide population-based cohort study. Diabetes Metab. Published 7 January 2025. doi:10.
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