Prediabetes and Fracture Risk Among Midlife Women in the Study of Women’s Health Across the Nation
Main finding · Fracture after start of the MTResult — go to the resultAdjusted hazard ratio 2.20 95% CI 1.11–4.37Authors' conclusion
This cohort study of midlife women suggests that prediabetes was associated with risk of fracture.
Study context
- Population
- Midlife women in premenopause or early perimenopause at inception without type 2 diabetes or bone-beneficial medications before the menopause transition (MT), Study of Women's Health Across the Nation, US multicenter; mean (SD) follow-up 12 (6) yearsmean age 49.7 years
- Participants
- 1,690 women
- Exposure
- Prediabetes before the MT vs no prediabetes before the MT
- Prediabetesn = 225
- No prediabetesn = 1,465reference
- Outcome
- Time to first fracture after the start of the MT
Methodological detailsmulticenter, longitudinal, Cox proportional hazards regression
- Multicenter
- Longitudinal
- Cox proportional hazards regression
Main finding
Fracture after start of the MT
Adjusted hazard ratio
2.20
95% CI 1.11–4.37
P = 0.02
Events by group
Prediabetesvs No prediabetes
aHR 2.20 (95% CI 1.11–4.37); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Original publication
Prediabetes and Fracture Risk Among Midlife Women in the Study of Women’s Health Across the Nation. JAMA Netw Open. Published 1 May 2023. doi:10.
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