Pragmatic Implementation of Online Obesity Treatment and Maintenance Interventions in Primary Care: A Randomized Clinical Trial
Authors' conclusion
Results of this randomized clinical trial indicate that pragmatic implementation of a 12-month automated, online, behavioral obesity treatment that includes 9 months of active maintenance produces clinically significant weight loss over 2 years in primary care patients with overweight or obesity. These findings underscore the importance of providing ongoing maintenance intervention to prevent weight regain.
Study context
- Population
- Primary care patients aged 18 to 75 years with overweight or obesity referred by their nurse care manager, Rhode Island primary care network, enrolled 2018–2020ITT analysis
- Participants
- 540 patients
- Comparison
- Monthly or refresher maintenance vs newsletter control maintenance after a 3-month automated online weight loss program (RxWL)
- Primary endpoint
- Weight change, from electronic medical record height and weight data
- Follow-up
- 12 months
Methodological detailspragmatic, primary care, Data analyzed August 2022 to September 2023
- Pragmatic
- Primary care
- Data analyzed August 2022 to September 2023
Primary result
As reported in the abstract
Monthly and Refresher vs Newsletter control: P = 0.004 · Monthly vs Refresher: difference not statistically significant
Further findings
Weight regain, per-protocol · 12 months
- Weight regain, per-protocol: per-protocol analysis of 253 participants
Weight loss after initial 3-month program (all participants)
- Mean estimated weight loss, kg
- 3.60 (95% CI, −4.32 to −2.88)
- Intention-to-treat analysis
Weight regain · 24 months
- The 12-month pattern persisted at 24 months
Weight loss after initial 3-month program, per-protocol
- Mean weight loss, kg
- 6.19 (95% CI, −7.25 to −5.13)
- Per-protocol analysis of 253 participants
Weight regain, per-protocol · 12 months
- Less weight regain with Monthly and Refresher than Newsletter control
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →