Patient-Delivered Continuous Care for Weight Loss Maintenance: A Randomized Clinical Trial
Authors' conclusion
In this trial, patient-delivered lifestyle intervention (mentor interventionists plus peer support) yielded significantly better WLM and cardiovascular risk outcomes compared with SOC delivered by professionals. Future research may examine the effectiveness of this novel treatment approach in community and clinical settings.
Study context
- Population
- Adults aged 18 to 75 years, BMI 25 to 50, who achieved ≥5% weight loss in a phase 1 online weight loss program; single academic research center; 83.6% female, mean age 53.6 years268 completed
- Participants
- 287 adults
- Comparison
- Patient-delivered lifestyle intervention (mentors plus peer support) vs professionally delivered standard-of-care (SOC) for weight loss maintenance
- Primary endpoint
- Weight change during the 18-month trial
- Follow-up
- 18 months
Methodological details2-phase weight loss maintenance (WLM) design, single academic research center, Data collected February 2018 to March 2023; analysed September 2024 to February 2025
- 2-phase WLM design
- Single academic research center
- Data collected February 2018 to March 2023; analysed September 2024 to February 2025
Primary result
As reported in the abstract
Weight change · month 18
Patient-to-patient
0.77
95% CI −0.14–1.68 · kg
SOC
2.37
95% CI 1.40–3.34 · kg
P = 0.002
Secondary outcomes
kg
| Outcome | Patient-to-patient | SOC |
|---|---|---|
| Weight change at month 6 | −1.44 (95% CI −2.35–0.54) | −0.16 (95% CI −1.13–0.82) |
| Weight change at month 12 | 0.04 (95% CI −0.86–0.95) | 0.77 (95% CI −0.21–1.47) |
Diastolic blood pressure, heart rate, physical activity and sedentary behavior
- Parallel findings were observed for diastolic blood pressure, heart rate, physical activity and sedentary behavior
Original publication
Patient-Delivered Continuous Care for Weight Loss Maintenance: A Randomized Clinical Trial. JAMA Intern Med. Published 1 July 2025. doi:10.
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