Adiposity indicators exhibit depot‐ and sex‐specific associations with multimorbidity onset: A cohort study of the UK Biobank
Authors' conclusion
Adiposity indicators are predictors of multimorbidity and comorbidity pairs and represent a promising approach for intervention.
Study context
- Population
- Adults without multimorbidity (≥2 chronic diseases) at baseline, UK Biobank
- Participants
- 382,678 adults
- Exposure
- Adiposity indicators and incident multimorbidity
- Outcome
- Incident multimorbidity
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
- Risk increase per one-unit increase in BMI
- 5.2% (95% CI 5.0%-5.4%)
- Risk increase per 0.1 increment in waist-to-height ratio
- 42.0% (37.9%-46.2%)
- Risk increase per 0.1 increment in WHR
- 27.9% (25.7%-30.0%)
- Increased risk with central obesity (waist circumference)
- 23.2%
- Risk increase with body fat percentage, all adults
- 3% (0.2%-5.9%)
- Risk increase with arm fat percentage, all adults
- 5.3% (0.8%-9.9%)
Observational data: associations, not effects.
Further findings
Incident multimorbidity by sex
- Risk increase with body fat percentage, females
- 5.3% (1.1%-9.7%)
- Risk increase with arm fat percentage, males
- 19.4% (11.0%-28.5%)
- Consistent findings for males and females
Onset of comorbidity pairs
- General obesity indices, waist circumference, waist-to-height ratio, WHR and central obesity increased onset of comorbidity pairs; hip circumference and hip-to-height ratio decreased it
- Adiposity indicators mainly affect DM-related comorbidity onset in males and hypertensive-related comorbidity onset in females
Original publication
Adiposity indicators exhibit depot‐ and sex‐specific associations with multimorbidity onset: A cohort study of the UK Biobank. Diabetes Obes Metab. Published 30 April 2024. doi:10.
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