Gestational diabetes & diabetes in pregnancy
Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy
Authors' conclusion
Postpartum weight retention predicts trajectories of worsening cardiovascular risk factors and glucose intolerance over the first 5-years after delivery, consistent with its postulated contribution to future vascular disease in women.
Study context
- Population
- Postpartum women (mean age 35.7 ± 4.3 years, mean pre-pregnancy BMI 25.2 ± 4.8 kg/m², 50.9% primiparous) with serial cardiometabolic characterization at 1, 3 and 5 years postpartum
- Participants
- 330 women
- Exposure
- Postpartum weight change categories
- Weight lossn = 100reference
- Weight gain 0-6%n = 110
- Weight gain ≥ 6%n = 120
- Outcome
- Cardiovascular risk factors (covariate-adjusted, stepwise worsening from weight loss to weight gain 0-6% to weight gain ≥ 6%)
- Follow-up
- 5-years postpartum
Main finding
As reported in the abstract
- Triglycerides
- p = 0.001
- HDL
- p = 0.02
- LDL
- p = 0.01
- Apolipoprotein-B
- p = 0.003
- Matsuda index
- p < 0.0001
- HOMA-IR
- p < 0.0001
- Fasting glucose
- p = 0.07
- C-reactive protein (CRP)
- p = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95% CI) | |
|---|---|---|
| Pre-diabetes/diabetes · 5-years postpartumWeight gain ≥ 6%vs Weight lossIndependent predictor on logistic regression | 3.40 (1.63–7.09) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Cardiovascular risk factors at 1-year postpartum
- Cardiovascular risk factors did not differ between the groups
Original publication
Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy. Cardiovasc Diabetol. Published 18 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →