Positive end‐expiratory pressure and postoperative complications in patients with obesity: a review and meta‐analysis
Authors' conclusion
It is unclear whether PEEP > 5 cm H2 O improves the postoperative clinical outcome in patients with obesity, which is in contrast to previously established evidence that it reduces atelectasis in patients with obesity.
Study context
- Population
- Adults with obesity undergoing surgery under general anesthesia with mechanical ventilation
- Participants
- 2,116 adults4 RCTs
- Comparison
- Positive end-expiratory pressure (PEEP) > 5 cm H2O vs PEEP ≤ 5 cm H2O
- Outcome
- Composite of postoperative pulmonary complications (PPCs):
- Atelectasis
- Pneumonia
- Pneumothorax
- Acute respiratory failure
Methodological detailsSearched Medline, Embase, CENTRAL and Cumulative Index to Nursing and Allied Health Literature (CINAHL); 903 titles and abstracts identified; analysis in ReviewManager (RevMan) version 5
- Searched Medline, Embase, CENTRAL and CINAHL; 903 titles and abstracts identified; analysis in RevMan version 5
Pooled result
PPCs
Relative risk
2.21
95% CI 0.41–11.83
P = 0.35
Between PEEP ≤ 5 cm H2O and PEEP > 5 cm H2O
RR 2.21 (95% CI 0.41–11.83); P = 0.35
As reported in the abstract
Original publication
Positive end‐expiratory pressure and postoperative complications in patients with obesity: a review and meta‐analysis. Obesity (Silver Spring). Published 28 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →