Population attributable fractions of modifiable risk factors for microvascular complications of type 2 diabetes in China: An analysis using national cross‐sectional data
Authors' conclusion
Suboptimal glycaemic and BP control were the main contributors to diabetic microvascular complications, while the PAFs of unmet LDL-C and BMI control targets were quite limited for diabetic microvascular complications. In addition to glycaemic control, BP control should be especially prioritized in the management of diabetic microvascular complications to further reduce the disease burden.
Study context
- Population
- Participants with T2D from nationwide mainland China, China National HbA1c Surveillance System 2009–2013
- Participants
- 998,379 participants
- Outcome
- PAFs of HbA1c ≥7%, BP ≥130/80 mmHg, LDL-C ≥1.8 mmol/L and BMI ≥24 kg/m² for DR, DKD and DSPN
Methodological detailsnational surveillance data, population attributable fractions (PAFs) adjusted for age, sex and duration of diabetes
- National surveillance data
- PAFs adjusted for age, sex and duration of diabetes
Main finding
As reported in the abstract
PAFs of modifiable risk factors for microvascular complications
- Diabetic retinopathy (DR): PAF of HbA1c ≥7%
- 16.2%
- DR: PAF of blood pressure (BP) ≥130/80 mmHg
- 15.2%
- DR: PAF of low-density lipoprotein-cholesterol (LDL-C) ≥1.8 mmol/L
- 5.8%
- DR: PAF of body mass index (BMI) ≥24 kg/m²
- 2.8%
- Diabetic kidney disease (DKD): PAF of BP ≥130/80 mmHg
- 25.2%
- DKD: PAF of HbA1c ≥7%
- 13.9%
- DKD: PAF of BMI ≥24 kg/m²
- 8.0%
- DKD: PAF of LDL-C ≥1.8 mmol/L
- 5.6%
- Distal symmetric polyneuropathy (DSPN): PAF of HbA1c ≥7%
- 14.2%
- DSPN: PAF of BP ≥130/80 mmHg
- 11.7%
- DSPN: PAF of LDL-C ≥1.8 mmol/L
- 5.9%
- DSPN: PAF of BMI ≥24 kg/m²
- 5.8%
Observational data: associations, not effects.
Further findings
PAFs after adjustment for age, sex and duration of diabetes
- PAFs mildly to moderately reduced after adjustment
Original publication
Population attributable fractions of modifiable risk factors for microvascular complications of type 2 diabetes in China: An analysis using national cross‐sectional data. Diabetes Obes Metab. Published 8 March 2023. doi:10.
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