Gestational diabetes & diabetes in pregnancy
PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content
Authors' conclusion
PNPLA3 rs738409 risk genotype completely decoupled the direct correlation between two surrogate markers of insulin resistance: TyG and HOMA2-IR confirming our hypothesis. The liver lipid content increased in parallel with the HOMA2-IR independent of genotype, in contrast to the TyG index where the risk genotype abolished the correlation. This phenomenon seems to be related to the nature of hepatic fat accumulation and to the different concepts establishing the two insulin resistance markers.
Study context
- Population
- Women from a prior GDM-genetic study recalled by PNPLA3 rs738,409 CC and GG genotypes; metabolic phenotyping with 75 g OGTT and hepatic triglyceride content (HTGC) by MR
- Participants
- 39 women
- Comparison
- PNPLA3 rs738409 GG vs CC genotype
- Outcome
- Correlations among TyG index, HOMA2-IR and hepatic triglyceride content (HTGC), stratified by PNPLA3 rs738409 genotype
Methodological detailsgenotype-stratified recall study
- Genotype-stratified recall study
Main finding
As reported in the abstract
Correlations of HOMA2-IR, TyG and HTGC
- HOMA2-IR vs TyG correlation, CC
- R = 0.52, p = 0.0054
- HOMA2-IR vs TyG correlation, GG
- completely abolished
- HOMA2-IR vs HTGC, entire population
- R = 0.69, p < 0.0001
- HOMA2-IR vs HTGC, CC
- R = 0.62, p = 0.0006
- HOMA2-IR vs HTGC, GG
- R = 0.74, p = 0.0058
- TyG vs HTGC, CC
- R = 0.42, p = 0.0284
- TyG vs HTGC, GG
- not significant
Further findings
TG vs HTGC correlation (TyG components assessed separately)
- TG vs HTGC, CC
- R = 0.41, p = 0.0335
- Similar pattern to TyG vs HTGC
Original publication
PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content. Cardiovasc Diabetol. Published 21 March 2023. doi:10.
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