Gestational diabetes & diabetes in pregnancy
Psychiatric Morbidity in Women With Previous Gestational Diabetes Mellitus: A Nationwide Register-Based Cohort Study
Authors' conclusion
GDM was associated with increased psychiatric morbidity risk. Subsequent diabetes development played a significant role in future psychiatric morbidity risk after GDM, although it only partly explained the association.
Study context
- Population
- All women delivering in Denmark from 1997 to 2018
- Participants
- 660,017 women
- Exposure
- Previous gestational diabetes mellitus (GDM) vs no previous GDM
- Outcome
- Incident psychiatric morbidity (diagnosis code and psychopharmacological medication use)
Methodological detailsmultiple Cox regression, mediation analyses
- Multiple Cox regression
- Mediation analyses
Main finding
As reported in the abstract
Incident psychiatric morbidity
Each group vs no GDMEstimate (95% CI)
GDM
aHR, depression (diagnosis code and/or medication use) 1.22(1.18–1.27)
GDM
aHR, any psychiatric diagnosis 1.20(1.13–1.27)
GDM
aHR, any psychopharmacological medication use 1.21(1.17–1.25)
Observational data: associations, not effects.
Further findings
Depressive and anxiety disorders; antidepressant and antipsychotic medication use
- Increased risk; aHRs ranging from 1.14 (95% CI 1.05-1.25) to 1.32 (95% CI 1.22-1.42)
Substance use, psychotic, bipolar disorders, postpartum psychiatric disease, anxiolytic use
- No associations found
Role of subsequent diabetes
- Proportion of GDM–psychiatric morbidity associations mediated by subsequent diabetes
- 35-42%
- Psychiatric morbidity risk higher in women with vs without subsequent diabetes; GDM history affected risk estimates only in women without subsequent diabetes
Original publication
Psychiatric Morbidity in Women With Previous Gestational Diabetes Mellitus: A Nationwide Register-Based Cohort Study. Diabetes Care. Published 16 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →