Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios Are Prognostic Markers for Pheochromocytomas and Paragangliomas
Authors' conclusion
Both elevated NLR and PLR are associated with poor prognosis in PPGLs. They are convenient predictive markers that could be used in daily clinical practice.
Study context
- Population
- Consecutive patients with PPGL, 2002–20201,247 evaluated
- Participants
- 728 patients
- Exposure
- High vs low preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR)
- Outcome
- Death
- Follow-up
- Median 63 months (IQR, 31-111 months)
Methodological detailsconsecutive patients, Cut-offs by X-tile software; Kaplan-Meier curves and Cox regression models
- Consecutive patients
- Cut-offs by X-tile software; Kaplan-Meier curves and Cox regression models
Main finding
As reported in the abstract
Deaths
31
Developed metastases
28
Developed recurrence
12
Observational data: associations, not effects.
Further findings
Overall survival (OS)
- Elevated NLR (≥3.5) and elevated PLR (≥217.4) associated with decreased OS
- P = 0.005
- NLR and PLR independent prognostic factors for OS (Cox models)
Metastasis-free survival
- Elevated PLR (≥238.3) associated with decreased metastasis-free survival (MFS)
- P = 0.021
- PLR independent prognostic factor for MFS (Cox models)
Original publication
Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios Are Prognostic Markers for Pheochromocytomas and Paragangliomas. J Clin Endocrinol Metab. Published 14 March 2023. doi:10.
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