Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis
Authors' conclusion
AMH may be sporadic or associated with MEN2, most have catecholamine excess and imaging abnormalities. Unilateral involvement is more common. Most reported patients have been treated with adrenalectomy, which is usually curative with regard to catecholamine hypersecretion.
Study context
- Population
- All published cases of adrenal medullary hyperplasia (AMH)29 reports
- Participants
- 66 participants
- Outcome
- Characteristics of AMH cases and genotype-phenotype relationships
Pooled result
As reported in the abstract
Characteristics of AMH cases
- Median age
- 48 years
- Male
- 59% (n = 39)
- Unilateral disease
- 73% (n = 48)
- Sporadic
- 71% (n = 47)
- Associated with MEN2
- 23% (n = 15)
- Signs and symptoms of catecholamine excess, particularly hypertension
- 91% (n = 60)
- Elevated catecholamine concentrations
- 86% (n = 57)
- Adrenal abnormalities on imaging
- 80% (n = 53)
- Concurrent tumors
- 58% (n = 38)
- Pheochromocytoma among concurrent tumors
- 42% (n = 16/38)
- MTC among concurrent tumors
- 24% (n = 9/38)
- Adrenocortical adenoma among concurrent tumors
- 29% (n = 11/38)
- Underwent adrenalectomy
- 88% (n = 58)
- Symptom resolution after adrenalectomy
- 45/58
Further pooled results
Adrenalectomy by age and laterality
- Adrenalectomy less common in patients under 40 years and those with bilateral disease
- both P < .05
Original publication
Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 10 March 2023. doi:10.
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