Plasma sphingolipids mediate the association between gut microbiome composition and type 2 diabetes risk in the HELIUS cohort: a case-cohort study
Authors' conclusion
These data suggest that sphingolipids mediate the association between microbiome and T2D risk. Future research is needed to confirm observed findings and elucidate causality on a molecular level.
Study context
- Population
- Participants of Dutch or South-Asian Surinamese ethnicity, aged 18–70 years, without T2D at baseline; HELIUS study
- Participants
- 176 vs 36
- Exposure
- Subcohort vs Incident T2D
- Subcohortn = 176reference
- Incident T2Dn = 36
- Outcome
- Mediation by sphingolipids of the association between gut microbiome and incident T2D
Methodological detailsmediation analysis with permutation testing and Bonferroni correction
- Mediation analysis with permutation testing and Bonferroni correction
Main finding
As reported in the abstract
Mediation of gut microbiome–T2D association
Mediation by sphingolipid principal component (dominance of ceramide species over more complex sphingolipids): HR (95% CI 1.08 to 1.28); proportion explained 48%
1.17
Mediation by Shannon diversity: HR (95% CI 0.95 to 0.99); proportion explained 24.8%
0.97
Observational data: associations, not effects.
Further findings
- Associations between gut microbiome and T2D and between sphingolipids and T2D confirmed; gut microbiome associated with sphingolipids
Original publication
Plasma sphingolipids mediate the association between gut microbiome composition and type 2 diabetes risk in the HELIUS cohort: a case-cohort study. BMJ Open Diabetes Res Care. Published 18 July 2024. doi:10.
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