Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling
Authors' conclusion
While HDL composition differed between controls and T2DM in both ethnic groups, the lower levels of lipid content in the smallest HDL subclass (HDL-4) in DSA with T2DM appeared to be more clinically relevant, with higher odds of having diabetes-related pan-microvascular complications such as retinopathy and neuropathy. These typical differences in HDL could be used as ethnicity-specific T2DM biomarkers.
Study context
- Population
- Healthy individuals and individuals with T2D of Dutch South Asian or Dutch white Caucasian descent51 healthy, 92 T2D
- Comparison
- Dutch South Asian (DSA) vs Dutch white Caucasian (DwC) individuals, with T2D vs healthy
- Outcome
- Association of HDL composition changes with microvascular risk in DSA with T2D
Methodological details1H NMR spectroscopy lipoprotein subclass profiling (B.I.LISA), multinomial logistic regression adjusted for confounders incl. BMI and diabetes duration
- 1H NMR spectroscopy lipoprotein subclass profiling (B.I.LISA)
- Multinomial logistic regression adjusted for confounders incl. BMI and diabetes duration
Main finding
As reported in the abstract
HDL composition
- High-density lipoproteins (HDL) compositional differences between healthy and diabetic individuals in both ethnic groups
- Apolipoprotein A2 and HDL-4 subfractions lower in DSA vs DwC with T2D
- In DSA with T2D, apolipoprotein A2 and HDL-4 subfractions negatively correlated with waist circumference, WHR, HbA1c, glucose and disease duration, and associated with increased incidence of microvascular complications
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling. Diabetes Obes Metab. Published 18 May 2023. doi:10.
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