Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
Authors' conclusion
Comorbid mental disorders in participants with DM are associated with an increased risk of HF. In addition, the association was stronger in a younger age group. Participants with DM and mental disorders should be monitored with increased frequency for signs of HF; for which they have a higher risk than the general population.
Study context
- Population
- Adults with diabetes mellitus (DM) who underwent health screening 2009–2012, Korean National Health Insurance Service; mental disorders: major depressive disorder, bipolar disorder, schizophrenia, insomnia or anxiety disorders
- Participants
- 2,447,386 adults
- Exposure
- Number of coexisting mental disorders vs none
- Outcome
- Incident HF
- Follow-up
- Median 7.09 years
Methodological detailsnationwide health insurance database, Cox proportional hazard modelling with confounder adjustment, competing risk analysis
- Nationwide health insurance database
- Cox proportional hazard modelling with confounder adjustment
- Competing risk analysis
Main finding
As reported in the abstract
HF
Each group vs 0 mental disordersAdjusted hazard ratio (95% CI)
1 mental disorder
1.222(1.207–1.237)
2 mental disorders
1.426(1.403–1.448)
≥3 mental disorders
1.667(1.632–1.70)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| HF by age subgroup1 mental disordervs 0 mental disordersAge <40 years | 1.301 (1.143–1.481) | ||
| HF by age subgroup≥2 mental disordersvs 0 mental disordersAge <40 years | 2.683 (2.257–3.190) | ||
| HF by age subgroup1 mental disordervs 0 mental disordersAge 40-64 years | 1.289 (1.265–1.314) | ||
| HF by age subgroup≥2 mental disordersvs 0 mental disordersAge 40-64 years | 1.762 (1.724–1.801) | ||
| HF by age subgroup1 mental disordervs 0 mental disordersAge ≥65 years | 1.164 (1.145–1.183) | ||
| HF by age subgroup≥2 mental disordersvs 0 mental disordersAge ≥65 years | 1.353 (1.330–1.377) | Pinter<0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Heart failure (HF) by age subgroup
- Association strongest in the younger age group
- Significant interactions with income, BMI, hypertension, CKD, history of CVD, insulin use and duration of DM
Original publication
Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study. Cardiovasc Diabetol. Published 18 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →