Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study
Authors' conclusion
Our proteome-wide association study identified galectin-4 to be associated with CHD and NCK1 to be associated with CIMT. Inflammatory pathways underlying the identified associations highlight the importance of inflammation in the development and progression of CHD.
Study context
- Population
- Participants of the KORA F4 study; replication in a matched case-control sample from the independent KORA F3 studydiscovery phase
- Participants
- 1,000 participants
- Outcome
- Associations of plasma protein levels with CHD (logistic regression) and with carotid intima-media thickness (CIMT; linear regression)
Methodological detailsdiscovery phase in KORA F4, replication in matched case-control sample (KORA F3), aptamer-based SOMAscan platform, Bonferroni correction
- Discovery phase in KORA F4
- Replication in matched case-control sample (KORA F3)
- Aptamer-based SOMAscan platform
- Bonferroni correction
Main finding
As reported in the abstract
Coronary heart disease (CHD), fully-adjusted model: galectin-4, OR
1.58 (1.30-1.93) (95% CI)
CHD, replication in KORA F3: galectin-4, OR
1.40 (1.09-1.88) (95% CI)
CIMT, fully-adjusted model: only NCK1 (NCK1) remained significant, β
0.017
p-value = 1.39e-06
Observational data: associations, not effects.
Further findings
Pathway analysis
- Upstream regulators of galectin-4 and NCK1 predicted to be involved in inflammation pathways
Original publication
Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study. Cardiovasc Diabetol. Published 29 May 2024. doi:10.
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