Abnormal vascular thickness and stiffness in young adults with type 1 diabetes: new insights from cutting-edge ultrasound modalities
Authors' conclusion
Young adults with T1D present with differences in arterial thickness and stiffness when compared with controls. Use of novel high-resolution ultrasound measures describe important relationships between early structural and vascular pathophysiologic changes and are promising tools to evaluate pre-clinical CVD risk in youth with T1D.
Study context
- Population
- Young adults with T1D and age and sex matched controls; mean age 24.1 years in both groups
- Participants
- 39 vs 25
- Exposure
- Young adults with T1D vs age and sex matched controls
- T1Dn = 39
- Controlsn = 25reference
- Outcome
- Vascular thickness and stiffness by high frequency ultrasound carotid intima-media thickness (CIMT) (hfCIMT) and ultrafast ultrasound PWV (ufPWV)
Methodological detailssingle-center, age and sex matched controls
- Single-center
- Age and sex matched controls
Main finding
As reported in the abstract
hfCIMT
P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| ufPWV (systolic foot PWV and dicrotic notch PWV)T1D vs Controls · significantly increased in T1D | P < 0.01 |
| ufPWV (systolic foot PWV and dicrotic notch PWV)T1D vs Controls · significantly increased in T1D | P < 0.01 |
ufPWV (systolic foot pulse wave velocity (PWV) and dicrotic notch PWV)
- ufPWV measures significantly increased in T1D
Associations with A1c-measured glycemia
- Impact of A1c-measured glycemia on hfCIMT, not seen with ufPWV
Correlation between hfCIMT and ufPWV
- No significant correlations between hfCIMT and ufPWV in either T1D or controls
Baseline characteristics
- Greater BMI in T1D vs controls
- 27.7 [5.7] vs 23.1 [3.2] kg/m²
- Mean A1c in T1D
- 7.4 [1.0] % (57 mmol/mol)
- Diabetes duration in T1D
- 16.1 [3.7] years
- Insulin pump use in T1D
- 56%
- T1D also had greater LDL cholesterol and estimated GFR
Original publication
Abnormal vascular thickness and stiffness in young adults with type 1 diabetes: new insights from cutting-edge ultrasound modalities. Cardiovasc Diabetol. Published 24 May 2024. doi:10.
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