Increased hepatic glucagon sensitivity in totally pancreatectomised patients
Authors' conclusion
Totally pancreatectomised patients were characterised by increased sensitivity to exogenous glucagon at the level of hepatic glucose, amino acid, and lipid metabolism, suggesting that the metabolic disturbances characterising these patients may be rooted in perturbed hepatic processes normally controlled by pancreatic glucagon.
Study context
- Population
- Middle-aged, normal-weight totally pancreatectomised patients, C-peptide-negative T1D patients and matched controls; fasting, basal insulin continued
- Participants
- 9 / 9 / 9
- Comparison
- 150-min IV glucagon infusion (4 ng/kg/min) vs placebo (saline), in totally pancreatectomised patients, T1D patients and matched controls
- Totally pancreatectomisedn = 9
- T1Dn = 9
- Controlsn = 9reference
- Outcome
- Responses to glucagon infusion
Methodological detailsplacebo-controlled, two separate experimental days, matched controls
- Placebo-controlled
- Two separate experimental days
- Matched controls
Main finding
As reported in the abstract
- Glucagon infusion increased plasma glucagon to similar high physiological levels in all groups
- Glucagon increased hepatic glucose production and decreased most plasma amino acids in all groups, more pronounced in totally pancreatectomised patients vs the other groups
- Glucagon diminished fatty acid re-esterification and tended to decrease plasma fatty acids in totally pancreatectomised patients but not in T1D patients
Original publication
Increased hepatic glucagon sensitivity in totally pancreatectomised patients. Eur J Endocrinol. Published 23 May 2024. doi:10.
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