Pituitary metastases: a case series and scoping review
Authors' conclusion
This scoping review showed that both radiosurgery and surgical resection have been frequently used to treat pituitary metastases with good response. Vision improvement is more likely to happen following surgical resection, likely at the expense of endocrine dysfunction. Despite treatment and radiographic response, patient survival remains less than a year.
Study context
- Population
- Patients with pituitary gland metastasis7 case series
- Outcome
- Case series and literature review results
Methodological detailsretrospective chart review, single-institution
- Retrospective chart review
- Single-institution
Main finding
As reported in the abstract
- Case series: patients identified
- seven
- Case series: average age
- 59.6 years
- Case series primary histologies: breast cancer
- 4
- Case series primary histologies: melanoma
- 1
- Case series primary histologies: renal cell carcinoma
- 1
- Case series primary histologies: sarcoma
- 1
- Case series: anterior pituitary endocrine dysfunction
- Two patients
- Case series: all treated with radiosurgery; also surgical resection
- two
- Case series: overall survival range
- 6.5 to 117 months
- Review: most common primary cancer lung
- 27.7%
- Review: breast primary
- 18.7%
- Review: renal primary
- 14.5%
- Review: endocrine dysfunction
- 107
- Review: diabetes insipidus
- 41
- Review: hypopituitarism
- 55
- Review: visual compromise
- 110
- Review: received radiotherapy
- 107
- Review: surgical resection
- 96
- Review: systemic chemotherapy/immunotherapy
- 44
- Review: median overall survival (range 0.2-96)
- 9.9 months
Observational data: associations, not effects.
Original publication
Pituitary metastases: a case series and scoping review. Pituitary. Published 12 September 2023. doi:10.
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