Pituitary metastasis as an endocrine–neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series
Authors' conclusion
Pituitary metastasis frequently presents with combined endocrine dysfunction and neuro-ophthalmologic compromise, occasionally as an acute sellar emergency.
Study context
- Population
- Patients diagnosed with pituitary metastasis, 2010–2025, tertiary centre; median age 52.5 years, 71.4% women
- Participants
- 14 consecutive patients
- Outcome
- Presentation and outcomes of pituitary metastasis
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
- Hypopituitarism at presentation
- 64.3%
- AVP-D at presentation
- 50.0%
- Visual impairment at presentation
- 50.0%
- Sudden bilateral visual loss and hemodynamic instability, mimicking an apoplexy-like sellar emergency
- 1 patient
- Breast cancer as most common primary tumour
- 28.6%
- Histopathologic confirmation
- 35.7%
- Median overall survival after diagnosis
- 6.5 months
- Died during follow-up
- 92.9%
Observational data: associations, not effects.
Original publication
Pituitary metastasis as an endocrine–neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series. Pituitary. Published 1 July 2026. doi:10.
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