Physical Activity and Weight Loss Among Adults With Type 2 Diabetes and Overweight or Obesity: A Post Hoc Analysis of the Look AHEAD Trial
Primary result · Composite cardiovascular outcomeResult — go to the resultHazard ratio 0.39 95% CI 0.19–0.81Authors' conclusion
In this cohort study, maintaining weight loss and higher PA volume was associated with a lower risk of the composite cardiovascular outcome. The findings suggest that the cardiovascular benefits of PA may vary and be enhanced by weight loss among individuals with T2D and overweight or obesity.
Study context
- Population
- Adults with T2D and overweight or obesity in the accelerometry-measured physical activity (PA) substudy of Look AHEAD; mean age 60 years, 43% male
- Participants
- 1,229 adults
- Comparison
- Maintained weight loss and high PA volume vs low PA volume and no weight loss
- High PA + weight lossn = 105
- Primary endpoint
- Composite of:
- Cardiovascular death
- Nonfatal MI
- Nonfatal stroke
- Hospitalization for angina
- Follow-up
- Median 9.5 years
Methodological detailscohort study, accelerometry substudy, 8 US locations, Conducted June 2001 to September 2012; data analyzed June to August 2023
- Cohort study
- Accelerometry substudy
- 8 US locations
- Conducted June 2001 to September 2012; data analyzed June to August 2023
Primary result
Composite cardiovascular outcome · median 9.5 years
Hazard ratio
0.39
95% CI 0.19–0.81
P = 0.01
High PA + weight lossvs Low PA, no weight loss
HR 0.39 (95% CI 0.19–0.81); P = 0.01
As reported in the abstract
- Participants experiencing the primary outcome overall
- 198 (16.1%)
- Multiplicative interaction between weight loss and PA
- P for interaction = 0.01
Original publication
Physical Activity and Weight Loss Among Adults With Type 2 Diabetes and Overweight or Obesity: A Post Hoc Analysis of the Look AHEAD Trial. JAMA Netw Open. Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →