Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial
Primary result · HbA1c reductionResult — go to the resultDifference −0.22 % 95% CI −0.39% to −0.06%Authors' conclusion
bMVPA performed in the afternoon is associated with improvements in glycemic control in adults with diabetes, especially within the initial 12 months of an intervention. Experimental studies are needed to examine causality.
Study context
- Population
- Adults with overweight/obesity and T2D with 7-day waist-worn accelerometry at year 1 or 4; 57% women, mean age 59 years
- Participants
- 2,416 adults
- Comparison
- Time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) timing groups vs inactive
- Primary endpoint
- Change in glycemic control (HbA1c)
- Follow-up
- 4 years
Methodological detailstime-varying exposure, 7-day waist-worn accelerometry
- Time-varying exposure
- 7-day waist-worn accelerometry
Primary result
HbA1c reduction · year 1
Difference
−0.22 %
95% CI −0.39% to −0.06%
Afternoonvs Inactive
difference −0.22 % (95% CI −0.39% to −0.06%)
As reported in the abstract
- HbA1c reduction at year 1 varied among bMVPA timing groups, independent of weekly bMVPA volume and intensity
- P = 0.02
Further findings
| Outcome | Odds ratio (95% CI) | |
|---|---|---|
| Discontinuationvs maintaining or initiating glucose-lowering medications · year 1Highest odds | 2.13 (1.29–3.52) | |
| 0.20.5125Odds ratio (log scale) |
- Discontinuation vs maintaining or initiating glucose-lowering medications — Odds differed by bMVPA timing
- P = 0.04
HbA1c change between year 1 and 4
- No significant changes in HbA1c for all the year-4 bMVPA timing groups
Original publication
Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial. Diabetes Care. Published 25 May 2023. doi:10.
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