Type 2 Diabetes Mellitus and Periodontitis: Bidirectional Association in Population-based 15-year Retrospective Cohorts
Authors' conclusion
We suggest that the bidirectional association is between T2DM and severe but not mild periodontitis.
Study context
- Population
- Patients in the National Health Insurance Research Database of Taiwan, 2000–2015
- Participants
- 11,011 / 11,011 / 11,011 / 157,798 / 157,798
- Exposure
- Severe or mild periodontitis vs non-periodontitis; T2D vs non-T2D
- Severe periodontitisn = 11,011
- Mild periodontitisn = 11,011
- Non-periodontitisn = 11,011reference
- T2DMn = 157,798
- Non-T2DMn = 157,798reference
- Outcome
- Development of T2D in periodontitis patients and of periodontitis in patients with T2D
Methodological detailsbidirectional cohorts, matched by age, sex, and index date, Cox proportional hazards model, Cox proportional hazards model
- Bidirectional cohorts
- Matched by age, sex, and index date
- Cox proportional hazards model
- Cox proportional hazards model
Main finding
As reported in the abstract
Risk of T2D (periodontitis cohorts) and of periodontitis (T2D cohort)
Adjusted hazard ratio (95% CI)P value
Severe periodontitisvs Non-periodontitisrisk of T2D
1.94(1.49–2.63)
P < 0.01Mild periodontitisvs Non-periodontitisrisk of T2D
1.72(1.24–2.52)
P < 0.01- Severe periodontitis vs Mild periodontitis · risk of T2D
- 1.17 (95% CI 1.04–1.26); P < 0.001
- T2DM vs Non-T2DM · risk of periodontitis
- 1.99 (95% CI 1.42–2.48); P < 0.01
Observational data: associations, not effects.
Further findings
Development of severe periodontitis
- High risk observed for the outcome of severe periodontitis
- 2.08 (95% CI 1.50-2.66, P < .001)
Development of mild periodontitis
- High risk not observed for mild periodontitis
- 0.97 (95% CI 0.38-1.57, P = .462)
Original publication
Type 2 Diabetes Mellitus and Periodontitis: Bidirectional Association in Population-based 15-year Retrospective Cohorts. J Clin Endocrinol Metab. Published 24 May 2023. doi:10.
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