Performance of FRAX in older adults with frailty: the Framingham Heart Study
Authors' conclusion
FRAX may have been less able to identify frail individuals at risk for fracture, as compared with individuals without frailty, unless information on BMD is available.
Study context
- Population
- Framingham Heart Study participants (older adults)
- Participants
- 3,554 participants
- Exposure
- FRAX performance in individuals with vs without frailty
- Frailtyn = 550
- Outcome
- Discrimination (AUC) and calibration of FRAX (v4.3) for MOF
- Follow-up
- 10-year follow-up
Methodological detailsstratified by frailty status, logistic regression AUC
- Stratified by frailty status
- Logistic regression AUC
Main finding
As reported in the abstract
AUC for FRAX (without BMD) for MOF
| Group | Value | AUC |
|---|---|---|
| Frailty | 0.584 (95% CI 0.504–0.663) | 0.584 |
| Without frailty | 0.695 (95% CI 0.649–0.741) | 0.695 |
Value
Frailty0.584 (95% CI 0.504–0.663)
Without frailty0.695 (95% CI 0.649–0.741)
AUC
Frailty0.584
Without frailty0.695
- Frailty vs Without frailty: P = 0.02
Observational data: associations, not effects.
Further findings
MOF incidence · 10-year follow-up
Mean
| Outcome | Frailty | Without frailty |
|---|---|---|
| Mean FRAX MOF score | 15.9% | 10.1% |
- AUC for FRAX with BMD, frailty subgroup
- 0.658
- AUC for FRAX with BMD, frailty subgroup — AUC improved vs FRAX without BMD
- p value < 0.01
Performance of FRAX for hip fracture
- Performance of FRAX for hip fracture was similar
Original publication
Performance of FRAX in older adults with frailty: the Framingham Heart Study. Osteoporos Int. Published 24 October 2023. doi:10.
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