Response regarding FRAX performance across race/ethnicity and genetic risk in the women’s health initiative
Study context
- Population
- Women in the Women's Health Initiative
- Comparison
- FRAX performance across race/ethnicity and polygenic-score groups
Methodological detailssecondary analysis of the Women's Health Initiative cohort, age-stratified analyses, competing-risk cumulative incidence, inverse probability of censoring weighting, Limitations: informative censoring differing across racial and ethnic groups, sparse subgroup events, multiple comparisons, limited cross-ancestry portability
- Secondary analysis of the Women's Health Initiative cohort
- Age-stratified analyses
- Competing-risk cumulative incidence
- Inverse probability of censoring weighting
- Limitations: informative censoring differing across racial and ethnic groups, sparse subgroup events, multiple comparisons, limited cross-ancestry portability
Primary result
As reported in the abstract
FRAX performance across race/ethnicity and genetic risk
- Age-stratified analyses showed a similar qualitative pattern of overestimation in Black and Hispanic/Latina women
- With medium polygenic-score group as reference, associations with major osteoporotic fracture remained directionally consistent
- IPCW estimates similar for major osteoporotic fracture but less stable for hip fracture
- Adding the polygenic score produced only modest gains in time-dependent discrimination
- Observed fracture probability estimated by cumulative incidence with death as a competing event
Original publication
Response regarding FRAX performance across race/ethnicity and genetic risk in the women’s health initiative. J Bone Miner Res. Published 12 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →