Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study
Authors' conclusion
Results from the PANDOME study thus far include the first reported screen-detected early-stage PC in a sporadic cohort. Our findings support the inclusion of a DD cohort in prospective PC screening studies in high-risk diabetes. Endocrinologists play an especially important role in the referral of individuals with DD.
Study context
- Population
- Individuals ≥50 years with new-onset or deteriorating diabetes, screened for pancreatic cancer with MRI/cholangiopancreatography625 screened
- Participants
- 109 individuals
- Exposure
- Deteriorating diabetes vs new-onset diabetes
- New-onset diabetes (NOD)n = 97reference
- Deteriorating diabetes (DD)n = 12
- Outcome
- Pancreatic cancer detection
- Follow-up
- 6-year period
Methodological detailspreliminary results, screening study
- Preliminary results
- Screening study
Main finding
As reported in the abstract
Pancreas biopsies for suspicious findings
4
3.6%
Overall detection rate
0.9%
1/109
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline characteristics, DD vs NODDD vs NOD · higher HbA1c with DD | P = 0.02 |
| Baseline characteristics, DD vs NODDD vs NOD · greater weight loss with DD | P = 0.0038 |
| Baseline characteristics, DD vs NODDD vs NOD · greater insulin requirements with DD | P < 0.0001 |
| Referral sourceEndocrinologists main referral source for DD | P < 0.001 |
Baseline characteristics, DD vs NOD
- DD cohort was older
Safety
- Detection rates of benign pancreatic abnormalities and incidental findings revealed no safety signals
Original publication
Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study. J Clin Endocrinol Metab. Published 29 May 2025. doi:10.
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