The Impact of Metformin on Plasma Prolactin Levels in Antipsychotics‐Treated Men With Hyperprolactinemia and Early‐Onset Androgenic Alopecia
Authors' conclusion
These findings suggest that androgen excess may attenuate metformin action on overactive lactotrophs in men with early-onset androgenic alopecia.
Study context
- Population
- Men with drug-induced hyperprolactinemia and T2D or prediabetes, treated with metformin for 6 months
- Participants
- 23 vs 22
- Exposure
- Metformin effect in men with normal hair growth (group A) vs late-onset androgenic alopecia (group B)
- Group An = 23reference
- Group Bn = 22
- Outcome
- Total and monomeric prolactin
- Follow-up
- 6 months
Methodological detailsgroups matched for age, HOMA-IR and prolactin concentration
- Groups matched for age, HOMA-IR and prolactin concentration
Main finding
As reported in the abstract
- Decrease in total and monomeric prolactin observed only in group A
- Degree of prolactin decrease correlated inversely with total, free and bioavailable testosterone, positively with baseline prolactin and with the impact on HOMA-IR
Observational data: associations, not effects.
Further findings
Glucose homeostasis (fasting glucose, HbA1c, HOMA-IR) · 6 months
- Reduced in both groups, more pronounced in group A
Baseline hormones · before metformin
- Group B had higher LH, LH/FSH ratio, testosterone (total, free, bioavailable) and DHEAS than group A
LH vs baseline · follow-up
- Follow-up LH higher in group A and lower in group B
Original publication
The Impact of Metformin on Plasma Prolactin Levels in Antipsychotics‐Treated Men With Hyperprolactinemia and Early‐Onset Androgenic Alopecia. Clin Endocrinol (Oxf). Published 28 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →