Overlooked complication of Cushing's syndrome: Reactivation of hepatitis B
Authors' conclusion
Since it is not always possible to achieve rapid remission in CS and these patients have long-term hypercortisolemia, we suggest that consensus should be reached on HBV serological assessment, standardization of follow-up, and planning of HBV prophylaxis in required instances in patients with CS especially in regions with a high prevalence of HBV infection.
Study context
- Population
- Patients with Cushing's syndrome (CS) (Adrenocorticotropic hormone (ACTH) dependent or independent) screened for hepatitis B virus (HBV) between 2016 and 2021
- Participants
- 72 patients
- Exposure
- Overt vs mild autonomous cortisol secretion (MACS) vs Remission
- Overtn = 26
- MACSn = 18
- Remissionn = 28
- Outcome
- Prevalence of HBV infection
Main finding
As reported in the abstract
HBV infection prevalence
Anti-HBc IgG positive
19
26.3%
Chronic HBV among anti-HBc IgG positive
4
Isolated anti-HBc IgG positive
15
HBsAg positive, all compatible with inactive chronic HBV
4
5.5%
Observational data: associations, not effects.
Safety
- HBV reactivation
- 2 patients
- HBV flare
- 1 patient
Original publication
Overlooked complication of Cushing's syndrome: Reactivation of hepatitis B. Clin Endocrinol (Oxf). Published 7 December 2022. doi:10.
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