Rates of Pheochromocytoma/Paraganglioma Screening in At-Risk Populations
Authors' conclusion
PPGL screening is pursued in roughly half of patients with adrenal nodules and hypertension, but rarely in patients with treatment-resistant or early-onset hypertension. Similar to screening for other forms of secondary hypertension, PPGL screening occurs more often after serious complications develop.
Study context
- Population
- Adults with hypertension in outpatient clinics of a large academic center (Jan 2017–Jun 2020) with treatment-resistant hypertension, hypertension at age <35 years and/or adrenal mass(es)of 203,535 with hypertension
- Participants
- 71,088 adults
- Exposure
- Screened vs not screened for pheochromocytomas and paragangliomas (PPGL)
- Screenedn = 2,013
- Outcome
- Rate of PPGL screening among eligible patients
Methodological detailssingle academic centre, outpatient clinics
- Single academic centre
- Outpatient clinics
Main finding
As reported in the abstract
PPGL screening rate
Eligible patients screened for PPGL
2013
2.83%
Screening rate, hypertension and adrenal mass(es)
51.7%
Screening rate, early-onset hypertension
3.9%
Screening rate, treatment-resistant hypertension
2.4%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics of screened vs not screened | P < 0.001 for all |
- Characteristics of screened vs not screened: younger (56.2 ± 17.4 vs 64.0 ± 17.1 years), more often women (54.1% vs 44.2%), never-smokers (54.6% vs 47.5%)
Predictors of PPGL screening (multivariable logistic regression)
- Women, OR
- 1.48 [1.34-1.63] (95% CI)
- Black vs White, OR
- 1.35 [1.19-1.53] (95% CI)
- Adrenal mass(es), OR
- 55.1 [44.53-68.15] (95% CI)
- Stroke, OR
- 1.34 [1.16-1.54] (95% CI)
- Dyslipidemia, OR
- 1.41 [1.26-1.58] (95% CI)
- CKD, OR
- 1.40 [1.26-1.56] (95% CI)
- Obstructive sleep apnea, OR
- 1.96 [1.76-2.19] (95% CI)
Original publication
Rates of Pheochromocytoma/Paraganglioma Screening in At-Risk Populations. J Clin Endocrinol Metab. Published 5 December 2022. doi:10.
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