Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population‐based study
Authors' conclusion
Careful consideration of important sources of bias suggests that a substantially larger share of the CRC burden may be attributable to excess weight than previously thought.
Study context
- Population
- Population-based colorectal cancer (CRC) cases and age- and sex-matched controls with comprehensive risk-factor information, including self-reported body weight
- Participants
- 7,098 vs 5,757
- Comparison
- Standard analysis vs analysis considering prediagnostic weight loss, history of lower GI endoscopy and increased CRC risk below BMI 25 kg/m²
- CRC casesn = 7,098
- Controlsn = 5,757reference
- Outcome
- Population attributable fraction of CRC cases attributable to overweight/obesity (higher BMI)
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Fraction of CRC cases attributable to overweight and obesity
Standard analysis (none of the three factors considered)
11.5%
All three factors considered (higher BMI)
23.4%
Observational data: associations, not effects.
Original publication
Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population‐based study. Obesity (Silver Spring). Published 10 December 2024. doi:10.
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