Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response
Authors' conclusion
Despite eliciting robust responses of appetite-reducing and/or satiety-promoting gut hormones, we found that oral glucose administration has little or no effect on appetite and satiety as compared to an IIGI, not affecting the release of appetite-modulating hormones.
Study context
- Population
- Healthy participants (6 women; mean age 55.1 [SD 14.2] years; mean BMI 26.7 [SD 2.2] kg/m²)crossover
- Participants
- 19 participants
- Comparison
- 50-g oral glucose tolerance test (OGTT) vs isoglycemic IV glucose infusion
- Outcome
- Difference in appetite and satiety sensations (visual analog scale (VAS)) during OGTT and IIGI
- Follow-up
- 0–3 h
Methodological detailstwo study days per participant
- Two study days per participant
Main finding
As reported in the abstract
- Hunger, satiety, fullness, thirst, well-being and nausea similar during OGTT and isoglycemic IV glucose infusion (IIGI) (mean 0-3-h values or AUC)
- Similar slow increase in appetite and decrease in satiation with both
- OGTT vs IIGI: P = 0.049
- OGTT vs IIGI: P = 0.044
- OGTT vs IIGI: P = 0.053
- OGTT vs IIGI: P = 0.063
Further findings
| Outcome | P value |
|---|---|
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · higher with OGTT | P < 0.0001 |
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · higher with OGTT | P < 0.0001 |
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · higher with OGTT | P < 0.0001 |
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · higher with OGTT | P < 0.0001 |
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · higher with OGTT | P = 0.003 |
| Gut and pancreatic hormone responses, OGTT vs IIGIOGTT vs IIGI · similarly suppressed | P = 0.991 |
Original publication
Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response. Eur J Endocrinol. Published 30 November 2023. doi:10.
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