Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case–control study
Authors' conclusion
Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.
Study context
- Population
- Educated patients with chronic adrenal insufficiency (AI)
- Participants
- 66 patients
- Comparison
- High vs low adrenal crises (AC) frequency
- High AC frequencyn = 34
- Low AC frequencyn = 32reference
- Outcome
- Susceptibility markers for AC
Main finding
As reported in the abstract
- Frequent AC patients had higher daily glucocorticoid doses and hair cortisol levels
- No significant differences in other parameters investigated
- AC frequency inversely correlated with frequency of self-reported adjustments of glucocorticoid replacement
Original publication
Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case–control study. Eur J Endocrinol. Published 24 November 2023. doi:10.
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