Quality of Life in Children With Congenital Adrenal Hyperplasia: A Tertiary‐Center Case‐Control Study
Authors' conclusion
Children and adolescents with CAH generally achieve HRQoL comparable to healthy peers under adequate treatment. Age-specific differences suggest younger children may experience preserved or enhanced physical well-being, while adolescents are vulnerable to reduced school functioning. These findings highlight the need for multidisciplinary, age-sensitive management strategies that include psychological and academic support, especially during adolescence.
Study context
- Population
- Children and adolescents aged 5–18 years with congenital adrenal hyperplasia (CAH) and healthy peers; age groups 5–6, 7–12 and 13–18 years
- Participants
- 25 vs 25
- Comparison
- Children and adolescents with CAH vs healthy controls
- CAHn = 25
- Controlsn = 25reference
- Outcome
- HRQoL by PedsQL 4.0 (child self-reports and parent proxy reports)
Methodological detailsfrequency-matched for age and sex, tertiary centre
- Frequency-matched for age and sex
- Tertiary centre
Main finding
As reported in the abstract
Overall HRQoL
- Overall, health-related quality of life (HRQoL) scores were similar between CAH patients and controls
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Physical functioning, age 7-12 yearsHigher with CAH | P = 0.037 |
| Total HRQoL, age 7-12 yearsHigher with CAH | P = 0.04 |
| School functioning, adolescentsLower with CAH | P = 0.03 |
School functioning, adolescents
- Other domains comparable
HRQoL by sex, ambiguous genitalia or glucocorticoid dose
- No significant differences in HRQoL by sex, ambiguous genitalia or glucocorticoid dose
Original publication
Quality of Life in Children With Congenital Adrenal Hyperplasia: A Tertiary‐Center Case‐Control Study. Clin Endocrinol (Oxf). Published 18 February 2026. doi:10.
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