Hemodynamic and microvascular abnormalities in P450 oxidoreductase deficiency: evidence for COX-dependent dysfunction
Authors' conclusion
PORD is associated with an increased prevalence of hypertension, microvascular capillary abnormalities, and elevated TXB₂, consistent with enhanced cyclooxygenase-mediated vasoconstrictor tone and endothelial dysfunction. These findings suggest that cyclooxygenase-dependent mechanisms may contribute to the vascular alterations observed in PORD.
Study context
- Population
- Patients with genetically confirmed cytochrome P450 oxidoreductase deficiency (PORD), a rare form of congenital adrenal hyperplasia, and age- and sex-matched healthy controls
- Participants
- 10 vs 41
- Exposure
- PORD vs healthy controls
- PORDn = 10
- Controlsn = 41reference
- Outcome
- Hypertension
Methodological detailsobservational, age- and sex-matched controls
- Observational
- Age- and sex-matched controls
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Nailfold capillaroscopy (NFC)PORD vs Controls | P = 0.001 |
| Nailfold capillaroscopy (NFC)PORD vs Controls | P < 0.001 |
| Nailfold capillaroscopy (NFC)PORD vs Controls | P = 0.039 |
| Serum TXB₂ | P = 0.007 |
Office and ambulatory (24-h ambulatory blood pressure monitoring (ABPM)) systolic and diastolic BP
- Office and ambulatory systolic and diastolic pressures significantly higher in PORD
Serum PGE₂ and nitric oxide (NO)
- PGE₂ and NO did not differ between groups
Original publication
Hemodynamic and microvascular abnormalities in P450 oxidoreductase deficiency: evidence for COX-dependent dysfunction. Eur J Endocrinol. Published 16 February 2026. doi:10.
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