Increased Prevalence of Accidents and Injuries in Congenital Adrenal Hyperplasia: A Population-based Cohort Study
Main finding · InjuriesResult — go to the resultRelative risk 1.34 95% CI 1.24–1.44Authors' conclusion
Patients with CAH had an increased prevalence of both injuries and accidents, especially in females and in those born before the neonatal screening program. Patients with nonclassic phenotype were hardly affected.
Study context
- Population
- Females and males with congenital adrenal hyperplasia (CAH) (21-hydroxylase deficiency) and matched controls, National Population-Based Registers; mean age 29.8 ± 18.4 yearsmatched cohort
- Participants
- 714 vs 71,400
- Exposure
- CAH vs matched controls
- CAHn = 714
- Controlsn = 71,400reference
- Outcome
- Prevalence of injuries and accidents
Methodological detailsmatched controls, national register linkage
- Matched controls
- National register linkage
Main finding
Injuries
Relative risk
1.34
95% CI 1.24–1.44
CAHvs Controls
relative risk 1.34 (95% CI 1.24–1.44)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Relative risk (CI) | |
|---|---|---|
| Injuries, femalesFemales | 1.43 (1.29–1.58) | |
| Injuries, malesMales | 1.25 (1.12–1.38) | |
| 0.512Relative risk (log scale) |
| Outcome | Estimate |
|---|---|
| Injuries, born before neonatal screeningSeen in both sexes | 1.48 (CI 1.35–1.62) |
| Injuries, born after neonatal screeningIncreased in females with CAH but not in males | 1.20 (CI 1.07–1.35) |
Injuries by phenotype and genotype
- Higher prevalence of injuries in classical phenotype, especially in females, but not in nonclassic phenotype
- In genotype groups, injuries mainly increased in females
Head injuries
- Head injuries increased in all patients with CAH and in the different phenotypes, mainly driven by females
Original publication
Increased Prevalence of Accidents and Injuries in Congenital Adrenal Hyperplasia: A Population-based Cohort Study. J Clin Endocrinol Metab. Published 20 October 2023. doi:10.
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