Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia
Authors' conclusion
Our findings indicate a decrease in leptin with the HC dose, consistent with a detrimental effect of glucocorticoid on satiety and hunger pathways in CAH. Adiponectin was decreased in patients with increased androgens concentrations, suggesting it may be used as an indicator of metabolic risk associated with poor hormonal CAH control.
Study context
- Population
- Children and young persons with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (54 females, 13.0 ± 2.92 years), 13 UK centres; fasted samples 09:00–11:00 after first glucocorticoid dose
- Participants
- 101 vs 83
- Exposure
- CAH patients vs matched controls
- CAHn = 101
- Controlsn = 83reference
- Outcome
- Adiponectin, leptin and resistin in relation to BMI, treatment, hormonal and metabolic biomarkers
Methodological detailsmulticentre, sex- and age-matched controls
- Multicentre
- Sex- and age-matched controls
Main finding
As reported in the abstract
Adipokines (leptin, adiponectin, resistin)
- Leptin positively related to BMI-SDS in patients and controls
- P < .001
- Adiponectin decreased with BMI only in patients
- P < .001
- Leptin decreased with increasing first daily hydrocortisone (HC) dose (Log10Leptin = 4.1- 0.08xfirstGCdose (mg/m²)), not with total daily dose
- P = .009
- BMI-corrected positive leptin–insulin relationship only in controls
- P < .001
Observational data: associations, not effects.
Original publication
Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia. Eur J Endocrinol. Published 8 August 2025. doi:10.
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