Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: a retrospective multicenter cohort study
An erratum to this article was published (Eur J Endocrinol, 5 Jun 2024 ↗)
Main finding · TART diagnosisResult — go to the resultrisk 2.6 times higherAuthors' conclusion
A delayed CAH diagnosis of >1 year vs CAH diagnosis within 1 month after birth was associated with a higher risk of TART development, which may be attributed to poor disease control in early life.
Study context
- Population
- Male patients with congenital adrenal hyperplasia (CAH) (21-hydroxylase deficiency, n = 181; 11-hydroxylase deficiency, n = 7), median age 13 years (IQR 10–17), at least 1 testicular US; data of first 4 years of life
- Participants
- 188 patients
- Exposure
- Delayed CAH diagnosis >1 year vs diagnosis within 1 month of life
- Outcome
- TART development
Methodological detailsmulticenter (n = 22), open cohort, I-CAH registry
- Multicenter (n = 22)
- Open cohort
- I-CAH registry
Main finding
TART diagnosis
risk
2.6 times higher
As reported in the abstract
- TART detected
- 72 (38%)
Observational data: associations, not effects.
Further findings
Biochemical disease control and bone age advancement in first 4 years · first 4 years of life
- Did not predict TART onset
Height SD scores at end of 4-year period · end of 4-year study period
- Increased height SD scores associated with higher risk of TART diagnosis
- 27%
Original publication
Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: a retrospective multicenter cohort study. Eur J Endocrinol. Published 14 October 2023. doi:10.
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