Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease
Authors' conclusion
Our results suggest that having AAD affects the baseline functional organization of the brain and that current treatment strategies of AAD may be one risk factor.
Study context
- Population
- Patients with autoimmune Addison disease and healthy controls, aged 19 to 43 years, scanned with 3-T magnetic resonance imaging (MRI)
- Participants
- 57 vs 69
- Exposure
- Autoimmune Addison disease (AAD) vs healthy controls
- AADn = 57
- Healthy controlsn = 69reference
- Outcome
- Resting-state functional connectivity (rs-fc) of the brain
Main finding
As reported in the abstract
Rs-fc (independent component and dual regression analyses)
- Stronger rs-fc with AAD vs controls in 3 networks: bilateral orbitofrontal cortex (OFC), left medial visual and left posterior default mode network
Observational data: associations, not effects.
Further findings
Glucocorticoid (GC) replacement dose and rs-fc in patients
- Higher GC replacement dose associated with stronger rs-fc in a small part of the left OFC
Rs-fc and executive functions or mental fatigue
- No clear associations between rs-fc and executive functions or mental fatigue
Original publication
Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease. J Clin Endocrinol Metab. Published 11 October 2023. doi:10.
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