One-Hour Plasma Glucose Predicts the Progression From Normal Glucose Tolerance to Prediabetes
Authors' conclusion
An increase in 1-h PG concentration precedes the development of prediabetes and identifies individuals with a 1-h PG of 120-155 mg/dL who are at increased risk of developing prediabetes. Therefore, we suggest the term pre-prediabetes for this group with an elevated risk of deteriorating glucose tolerance.
Study context
- Population
- San Antonio Heart Study participants free of T2D at baseline, with baseline oral glucose tolerance test (OGTT) and repeat OGTT after 7.5 years; prediabetes by ADA criteria
- Participants
- 1,557 participants
- Exposure
- 1-h plasma glucose (PG) <155 mg/dL vs >155 mg/dL during OGTT
- Outcome
- Progression from NGT to prediabetes (ADA criteria), predicted by 1-h PG
- Follow-up
- 7.5 years
Methodological detailspopulation-based, 7.5-year follow-up
- Population-based
- 7.5-year follow-up
Main finding
As reported in the abstract
Progression from NGT to prediabetes
- Participants with normal glucose tolerance (NGT) progressing to prediabetes, overall
- 24.7%
- Sensitivity of 1-h cut point of 120 mg/dL
- 61%
- Specificity of 1-h cut point of 120 mg/dL
- 67%
Observational data: associations, not effects.
Further findings
Characteristics of progressors with 1-h PG 120-155 mg/dL
- Severe insulin resistance and metabolic abnormalities of the insulin resistance syndrome; authors suggest the term pre-prediabetes
Original publication
One-Hour Plasma Glucose Predicts the Progression From Normal Glucose Tolerance to Prediabetes. Diabetes Care. Published 16 May 2025. doi:10.
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