Oral Glucose Tolerance Test (OGTT) ‐Derived β‐Cell Function–Based Stratification of 2‐Year Glycaemic Transitions in Chinese Adults With Prediabetes
Authors' conclusion
ISSI-2 was associated with baseline glycaemic profiles and bidirectional 2-year transitions in Chinese adults with prediabetes.
Study context
- Population
- Chinese adults with prediabetes and complete baseline OGTT glucose and insulin measurements, multicentre lifestyle intervention cohort410 with 2-year outcomes
- Participants
- 645 adults
- Exposure
- ISSI-2 and homeostasis model assessment of insulin resistance (HOMA-IR) in relation to baseline glycaemia and 2-year glycaemic transitions
- Outcome
- 2-year progression to diabetes or reversion to normoglycemia
- Follow-up
- 2 years
Methodological detailsmulticentre, lifestyle intervention cohort, multivariable regression
- Multicentre
- Lifestyle intervention cohort
- Multivariable regression
Main finding
As reported in the abstract
Progressed to diabetes
136 participants
Reverted to normoglycemia
61 participants
Progression risk per 1-SD increase in ISSI-2, OR
0.505 (0.382-0.668) (95% CI)
Reversion likelihood per 1-SD increase in ISSI-2, OR
1.447 (1.106-1.893) (95% CI)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Progression risk by index-based group · 2 yearsDual-defect (higher HOMA-IR and lower ISSI-2)vs Low IR + higher ISSI-2 | 2.764 (1.459–5.237) | |
| 0.20.5125Odds ratio (log scale) |
Baseline glycaemic measures vs ISSI-2
- 1-h PG, β per 1-SD increase in ISSI-2 (strongest association)
- −1.189 mmol/L; p < 0.001
- Higher ISSI-2 associated with lower FPG, 1-h PG, 2-h PG and HbA1c
Original publication
OGTT ‐Derived β‐Cell Function–Based Stratification of 2‐Year Glycaemic Transitions in Chinese Adults With Prediabetes. Diabetes Obes Metab. Published 13 September 2026. doi:10.
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