Obstructive sleep apnea (OSA) is associated with increased risk of early-onset sarcopenia and sarcopenic obesity: Results from National Health and Nutritional Examination Survey (NHANES) 2015-2018
Authors' conclusion
Early-onset sarcopenia and sarcopenic obesity were prevalent among young adults in the US. OSA is a significant independent risk factor and may induce muscle loss by unhealthy diet habits, higher BMI, chronic inflammation, insulin resistance, and Vitamin D. It was essential for clinicians to arrange appropriate screening and interventions for patients with OSA to prevent muscle loss as early as possible.
Study context
- Population
- Young adults in the US, NHANES 2015–2018
- Exposure
- OSA vs no OSA
- Outcome
- Prevalence of early-onset sarcopenia and sarcopenic obesity, and association of OSA with early-onset sarcopenia
Methodological detailsweighted multistage stratified probability sampling, weighted multivariable logistic regression, weighted multivariable mediation models
- Weighted multistage stratified probability sampling
- Weighted multivariable logistic regression
- Weighted multivariable mediation models
Main finding
As reported in the abstract
- Prevalence of early-onset sarcopenia
- 5.5%
- Prevalence of early-onset sarcopenic obesity
- 4.6%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Prevalence of early-onset sarcopenia, OSA vs no OSAHigher prevalence with OSA | P < 0.01 |
| Prevalence of early-onset sarcopenic obesity, OSA vs no OSAHigher prevalence with OSA | P < 0.01 |
Prevalence of early-onset sarcopenia, OSA vs no OSA
- Higher prevalence of sarcopenia among participants with OSA than those without OSA
Prevalence of early-onset sarcopenic obesity, OSA vs no OSA
- Higher prevalence of sarcopenic obesity among participants with OSA than those without OSA
Mediation of OSA effects on early-onset sarcopenia and sarcopenic obesity, respectively
- Serum chronic reaction protein (CRP) mediated (sarcopenia & sarcopenic obesity)
- 23.7% (P < 0.01) & 26.2% (P < 0.01)
- HOMA-IR mediated (sarcopenia & sarcopenic obesity)
- 24.8% (P < 0.01) & 20.7% (P < 0.05)
- Body mass index (BMI) mediated (sarcopenia & sarcopenic obesity)
- 46.4% (P < 0.05) & 49.9% (P < 0.01)
- HEI-2015 mediated (sarcopenia & sarcopenic obesity)
- 23.3% (P < 0.01) & 25.6% (P < 0.01)
- Vitamin D mediated (sarcopenia & sarcopenic obesity)
- 7.5% (P < 0.01) & 8.5% (P < 0.01)
Original publication
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