Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) metrics
Authors' conclusion
Increased brain perfusion in individuals with obesity is associated with cognitive function and mental health through interaction with metabolic and inflammatory factors.
Study context
- Population
- Individuals with and without obesity
- Participants
- 72 vs 66
- Exposure
- Individuals with obesity vs healthy controls
- Obesityn = 72
- Healthy controlsn = 66reference
- Outcome
- Brain fractional perfusion (FP) by IVIM MRI
Methodological detailsIVIM MRI, Boruta analysis (artificial intelligence algorithms)
- IVIM MRI
- Boruta analysis (artificial intelligence algorithms)
Main finding
As reported in the abstract
Brain FP
- Increased fractional perfusion (FP) with obesity within dopaminergic brain circuits, particularly prefrontal cortex areas, anterior and posterior cingulate cortex, right striatum and midbrain
Observational data: associations, not effects.
Further findings
Working memory and depressive symptoms
- Lower working memory and higher depressive symptoms with obesity vs controls
FP correlations with cognition and depression
- Higher FP in inferior temporal and occipital cortices correlated with greater depressive symptoms
- Increased FP in right ventral caudate and midbrain associated with better working memory
Boruta analysis
- Link between inflammatory and metabolic variables, especially monocytes, and FP in obesity
Original publication
Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics. Obesity (Silver Spring). Published 21 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →