Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli
Authors' conclusion
This study reveals VN-DAN-SUB dynamic interactions in aversion processing, emphasizing the indirect pathway's key role. Inefficient VN-DAN-SUB coordination in obesity may impair aversive food stimuli regulation, supporting the emotion regulation deficit hypothesis
Study context
- Population
- Participants with obesity and healthy participants viewing spoiled food videos in an MRI scanner
- Participants
- 30 vs 35
- Exposure
- Participants with obesity vs healthy participants
- Obesityn = 30
- Healthy controln = 35reference
- Outcome
- Integration between visual (VN), dorsal attention (DAN) and subcortical (SUB) networks while viewing spoiled food videos
Methodological detailsMRI, dynamic network analysis
- MRI
- Dynamic network analysis
Main finding
As reported in the abstract
- Obesity showed significantly lower VN, dorsal attention (DAN) and subcortical (SUB) integration than healthy controls
Observational data: associations, not effects.
Further findings
DAN-SUB integration and clinical measures
- DAN-SUB integration correlated positively with body image distress and negatively with craving ratings
- DAN-SUB integration moderated the predictive link between cognitive impulsivity and eating disorders
Granger causality analysis
- Dominant indirect pathway with stronger effective connectivity, with differential spatial associations with neurotransmitter receptors (α4β2, mGluR5, NMDA, CB1)
Original publication
Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli. Obesity (Silver Spring). Published 14 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →