Observational and genetic associations of adiposity with cardiopulmonary multimorbidity: Linear and nonlinear Mendelian randomization analysis
Main finding · Incident CP-MM (observational)Result — go to the resultHazard ratio 1.51 95% CI 1.30–1.75Authors' conclusion
Adiposity may play a causal role in CP-MM development and represent a promising approach for multimorbidity prevention.
Study context
- Population
- UK Biobank participants with complete phenotypic and genetic data1,492 incident cardiopulmonary multimorbidity (CP-MM)
- Participants
- 408,886 participants
- Exposure
- Adiposity traits and incident cardiopulmonary multimorbidity
- Outcome
- Incident cardiopulmonary multimorbidity (CP-MM)
- Follow-up
- Median 8.7 years
Methodological detailsUK Biobank, Cox regression, linear and nonlinear Mendelian randomization
- UK Biobank
- Cox regression
- Linear and nonlinear Mendelian randomization
Main finding
Incident CP-MM (observational)
Hazard ratio
1.51
95% CI 1.30–1.75
Obesityvs Normal BMI
HR 1.51 (95% CI 1.30–1.75)
As reported in the abstract
- Linear Mendelian randomization (MR): 1 kg/m² increase in genetically predicted body mass index (BMI), higher risk of incident CP-MM
- 9%
- Linear MR: per 1% higher genetically predicted WHRadjBMI, higher risk of incident CP-MM
- 10%
Observational data: associations, not effects.
Further findings
Shape of association (restricted cubic spline)
- U-shaped relationship between continuous BMI and CP-MM
- P < 0.001
- Linear relationship for WHRadjBMI
- P = 0.828
Joint analysis of overweight and waist-hip ratio (WHR)
- Maintaining ideal WHR in adults with overweight still effective in preventing CP-MM
Nonlinear MR
- Linearity between genetically predicted BMI or WHRadjBMI and CP-MM
Original publication
Observational and genetic associations of adiposity with cardiopulmonary multimorbidity: Linear and nonlinear Mendelian randomization analysis. Obesity (Silver Spring). Published 5 November 2023. doi:10.
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