Obesity‐related inflammatory protein signature in cardiovascular clinical outcomes: results from the Gutenberg Health Study
Authors' conclusion
The OIPS showed a significant association with adverse clinical outcomes, particularly in those with overweight and obesity, and represents a promising tool for identifying patients at higher risk for worse cardiovascular outcomes.
Study context
- Population
- Participants of the population-based Gutenberg Health Study (GHS); external validation in the MyoVasc studyGHS
- Participants
- 6,662 participants
- Outcome
- Association of an obesity-related inflammatory protein signature (OIPS) with adverse cardiovascular events
Methodological detailspopulation-based, external validation in the MyoVasc study
- Population-based
- External validation in the MyoVasc study
Main finding
As reported in the abstract
- OIPS of 21 proteins involved in chemokine activity, tumor necrosis factor (TNF) receptor binding and growth factor receptor binding
- Novel positive association of axis inhibition protein 1 with obesity
- OIPS associated with increased risk of all-cause and cardiac deaths, MACE and incident coronary artery disease, independent of clinical covariates and established risk instruments
Observational data: associations, not effects.
Further findings
BMI-stratified analysis
- OIPS associated with increased death in those with obesity and overweight, and with increased coronary artery disease risk in those with obesity
External validation (MyoVasc cohort)
- Association of OIPS with increased risk of all-cause and cardiac deaths validated
Original publication
Obesity‐related inflammatory protein signature in cardiovascular clinical outcomes: results from the Gutenberg Health Study. Obesity (Silver Spring). Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →