Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults
Authors' conclusion
Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin.
Study context
- Population
- Children and young adults with pituitary stalk interruption syndrome (PSIS), Toulouse cohort 1984–2019
- Participants
- 69 children
- Exposure
- PSIS with obesity/overweight vs PSIS without obesity/overweight
- OB-OWn = 25
- NOn = 44reference
- Outcome
- History of neonatal hypoglycemia
Methodological detailssingle-centre cohort
- Single-centre cohort
Main finding
As reported in the abstract
P = 0.0008
Observational data: associations, not effects.
Further findings
Extrapituitary malformations · more common with OB-OW
P < 0001
Caesarean section · higher with OB-OW, not significant
P = 0.07
Growth retardation as main reason for consultation
Cohort characteristics
- Sex ratio
- 1.6
- All cases sporadic
Original publication
Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults. J Clin Endocrinol Metab. Published 6 October 2022. doi:10.
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